Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300738 | 0.90 | MMP13 (0.48) | MMP13MMP1KMT2AMEN1 | |
| SCHEMBL7201014 | 0.90 | SMN1; SMN2 (0.41) | MMP13MMP1KMT2AAKR1C3AKR1C1 | |
| SCHEMBL7202567 | 0.88 | MMP13 (0.40) | MMP13F10MMP1ICMTKMT2A | |
| SCHEMBL7290273 | 0.88 | MGLL (0.41) | MMP13F10MMP1KMT2AKDM2B | |
| SCHEMBL7201767 | 0.88 | NAAA (0.44) | MMP13F10KMT2AKDM2BGRIN2B | |
| SCHEMBL7205634 | 0.86 | MMP13 (0.55) | MMP13MMP1 | |
| SCHEMBL7203105 | 0.85 | MMP13 (0.38) | MMP13MMP1 | |
| SCHEMBL7201540 | 0.83 | ADAMTS4 (0.39) | MMP13MMP1RORC | |
| SCHEMBL7204066 | 0.83 | ALDH1A1 (0.38) | MMP13MMP1KMT2A | |
| SCHEMBL7204213 | 0.83 | MMP13 (0.52) | MMP13MMP1KDM2BRORCAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608104-B2 | Antiarthritic agents; anticancer agents | PFIZER INC | 2003-08-19 | — | — | US | disclosed |
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |