SCHEMBL7210308

SCHEMBL7210308

COc1ccc([CH]Cc2ccc3ccccc3c2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.52
CYP1A2 P05177 2/20 0.52
RAB9A P51151 2/20 0.51
NQO2 P16083 2/20 0.49
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TRPA1 O75762 1/20 0.44
LTA4H P09960 1/20 0.44
POLB P06746 1/20 0.44
PPARG P37231 1/20 0.44
NCOA2 Q15596 1/20 0.44
NCOA1 Q15788 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
NCOA3 Q9Y6Q9 1/20 0.44
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TP53 P04637 1/20 0.43
CYP3A4 P08684 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8710672 0.83 CYP1A2 (0.50) CYP2A6CYP1A2RAB9AKMT2A
SCHEMBL8668861 0.83 RAB9A (0.51) CYP2A6CYP1A2RAB9ANQO2KMT2A
SCHEMBL1930129 0.82 ALDH1A1 (0.61) CYP2A6CYP1A2NQO2TRPA1LTA4H
SCHEMBL8598224 0.81 NQO2 (0.50) CYP2A6CYP1A2NQO2MEN1KMT2A
SCHEMBL2123173 0.81 LTA4H (0.57) CYP2A6RAB9AMEN1KMT2ATRPA1
SCHEMBL5580077 0.81 LTA4H (0.57) CYP2A6RAB9AKMT2ATRPA1LTA4H
SCHEMBL7764479 0.80 RAB9A (0.46) CYP2A6CYP1A2RAB9AKMT2A
SCHEMBL4949651 0.80 RELA (0.54) CYP2A6RAB9AALDH1A1SMN1; SMN2TP53
SCHEMBL7220223 0.80 CYP1A2 (0.48) CYP2A6CYP1A2RAB9AALDH1A1L3MBTL1
SCHEMBL8710305 0.79 TRPA1 (0.50) CYP2A6RAB9AKMT2ATRPA1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974595-B1 PROCESS FOR PRODUCING BORON COMPOUNDS SHOWA DENKO KK (JP) 2003-10-01 EP disclosed