SCHEMBL7211586

SCHEMBL7211586

CNCCc1ccccc1NS(=O)(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 2/20 0.56
ALDH1A1 P00352 4/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TSHR P16473 2/20 0.51
POLB P06746 2/20 0.51
SLC6A2 P23975 1/20 0.48
HTR2A P28223 1/20 0.48
SLC40A1 Q9NP59 1/20 0.48
RECQL P46063 1/20 0.47
KMT2A Q03164 1/20 0.46
SLC16A3 O15427 1/20 0.45
TAAR1 Q96RJ0 3/20 0.45
IL1RN P18510 1/20 0.44
KEAP1 Q14145 1/20 0.44
ERAP1 Q9NZ08 1/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
USP2 O75604 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10438570 0.84 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2TSHRPOLBRECQL
SCHEMBL7647398 0.83 TAAR1 (0.50) ALDH1A1SLC6A2HTR2AKMT2ATAAR1
SCHEMBL10272404 0.82 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2TSHRPOLBRECQL
SCHEMBL6900797 0.81 METAP2 (0.56) ALDH1A1SMN1; SMN2TSHRPOLBRECQL
Methane SCHEMBL7208092 0.79 HTR6 (0.56) HTR6ALDH1A1SMN1; SMN2TSHRPOLB
SCHEMBL13416386 0.79 MEN1 (0.61) HTR6ALDH1A1SMN1; SMN2TSHRPOLB
SCHEMBL3897238 0.78 KEAP1 (0.55) ALDH1A1TSHRPOLBKMT2ASLC16A3
Hydrochloric Acid SCHEMBL27582062 0.78 MEN1 (0.60) HTR6ALDH1A1SMN1; SMN2TSHRPOLB
SCHEMBL12050285 0.77 RECQL (0.57) ALDH1A1SMN1; SMN2TSHRPOLBRECQL
SCHEMBL27478563 0.77 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2TSHRPOLBSLC40A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077935-B1 PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS UPJOHN CO (US) 2003-10-29 EP disclosed
EP-0923539-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2002-06-05 EP disclosed
EP-1184370-A2 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2002-03-06 EP disclosed
US-6274584-B1 PEPTIDE DERIVATIVES; BIOAVAILABILITY; ENZYME RESISTANCE; MILK AND WOOL PRODUCTION NOVO NORDISK A/S (DK) 2001-08-14 US disclosed
US-6127354-A FOR TREATMENT OF GROWTH DISORDERS OR TO STIMULATE PRODUCTION OF WOOL OR MILK NOVO NORDISK A/S (DK) 2000-10-03 US disclosed
US-5922770-A NOVEL COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY NOVO NORDISK A/S (DK) 1999-07-13 US disclosed
EP-0923539-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-06-23 EP disclosed
WO-1998003473-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1998-01-29 WO disclosed