SCHEMBL7213458

SCHEMBL7213458

O=S(=O)(CCCS)c1ccccc1Sc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 4/20 0.63
MMP8 P22894 3/20 0.63
MMP3 P08254 2/20 0.63
MMP1 P03956 2/20 0.44
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NSD2 O96028 1/20 0.38
MAPK1 P28482 1/20 0.38
SIRT1 Q96EB6 1/20 0.36
ALDH1A1 P00352 2/20 0.34
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
BLM P54132 1/20 0.34
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CA2 P00918 5/20 0.33
CA4 P22748 5/20 0.33
CA12 O43570 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208413 0.84 MMP13 (0.44) MMP13MMP8MMP3MMP1MAPT
SCHEMBL7213456 0.78 MMP13 (1.00) MMP13MMP8MMP3MMP1MAPT
SCHEMBL7212096 0.72 MMP8 (0.47) MMP13MMP8MMP3MMP1KDM4E
SCHEMBL5013613 0.71 CA2 (0.51) MAPTKDM4ENSD2MAPK1SIRT1
SCHEMBL10413097 0.71 SIRT1 (0.47) MAPTKDM4ENSD2MAPK1SIRT1
SCHEMBL5683257 0.71 MAPT (0.46) MAPTKDM4ENSD2MAPK1SIRT1
SCHEMBL10789247 0.71 MAPT (0.46) MAPTKDM4ENSD2MAPK1SIRT1
SCHEMBL7207566 0.70 MMP8 (0.71) MMP13MMP8MMP3MMP1MAPT
SCHEMBL9626218 0.69 HTR6 (0.50) MAPTKDM4ENSD2MAPK1SIRT1
SCHEMBL7208689 0.69 MMP8 (0.63) MMP13MMP8MMP3MMP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0939628-B1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO CO (US) 2003-03-05 EP disclosed
US-6013649-A BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS MONSANTO COMPANY (US) 2000-01-11 US disclosed
EP-0939628-A4 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO CO (US) 1999-12-22 EP disclosed
EP-0939628-A1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO COMPANY (US) 1999-09-08 EP disclosed
WO-1998003164-A1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO COMPANY (US) 1998-01-29 WO disclosed