SCHEMBL7214149

SCHEMBL7214149

CCOC(=O)c1cc2nc(Cl)ccc2n1S(=O)(=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 5/20 0.62
NOD1 Q9Y239 5/20 0.62
ALDH1A1 P00352 3/20 0.45
NPSR1 Q6W5P4 2/20 0.45
MAPT P10636 1/20 0.45
ALOX15 P16050 1/20 0.45
KDM4E B2RXH2 2/20 0.41
LMNA P02545 2/20 0.41
TSHR P16473 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
ALDH3A1 P30838 2/20 0.40
PPARG P37231 2/20 0.40
PPARA Q07869 2/20 0.40
PPARD Q03181 1/20 0.40
AR P10275 1/20 0.40
HTT P42858 2/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
SIRT2 Q8IXJ6 1/20 0.40
SIRT1 Q96EB6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26620160 0.91 NOD1 (0.64) NOD2NOD1ALDH1A1NPSR1MAPT
SCHEMBL16254657 0.88 NOD1 (0.46) NOD2NOD1ALDH1A1MAPTKDM4E
SCHEMBL30883100 0.85 NOD2 (0.47) NOD2NOD1ALDH1A1NPSR1MAPT
SCHEMBL16818895 0.85 NOD1 (0.43) NOD2NOD1ALDH1A1MAPTKDM4E
SCHEMBL16818821 0.84 CCR2 (0.52) NOD2NOD1ALDH1A1MAPTKDM4E
SCHEMBL2347003 0.82 NOD2 (0.78) NOD2NOD1PPARGPPARAPPARD
SCHEMBL2542152 0.80 NOD2 (0.86) NOD2NOD1ALDH1A1NPSR1MAPT
SCHEMBL16818904 0.80 ALDH3A1 (0.50) NOD2NOD1ALDH1A1KDM4ELMNA
SCHEMBL29526316 0.80 ALDH3A1 (0.50) NOD2NOD1ALDH1A1KDM4ELMNA
Benzenesulfonamide SCHEMBL8938299 0.78 NOD2 (0.70) NOD2NOD1PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2021-08-17 US disclosed
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors INCYTE CORPORATION (US) 2021-08-17 US disclosed
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2019-10-15 US disclosed
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2019-10-15 US disclosed
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2018-01-04 US disclosed
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2018-01-04 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-9777003-B2 Tricyclic heterocycles as bet protein inhibitors INCYTE CORPORATION (US) 2017-10-03 US disclosed
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION 2016-06-16 US disclosed
US-6602864-B1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-08-05 US disclosed
EP-0944386-B1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMACEUTICALS PRODUCTS INC. 2002-01-31 US disclosed
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP disclosed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US disclosed
EP-0944386-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2001-04-11 EP disclosed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP disclosed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO disclosed
EP-0944386-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-09-29 EP disclosed
WO-1998025611-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-06-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180002334-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS BRD1, BRD3, BRD2 NOD2 1082/4885NOD1 1307/4885ALDH1A1 4703/4885
US-10442803-B2 Tricyclic heterocycles as bet protein inhibitors BRD1, BRD3, BRD2 NOD2 1082/4885NOD1 1307/4885ALDH1A1 4703/4885
US-20160168148-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS BRD1, BRD3, BRD2 NOD2 1082/4885NOD1 1307/4885ALDH1A1 4703/4885
US-11091484-B2 Tricyclic heterocycles as BET protein inhibitors BRD1, BRD3, BRD2 NOD2 1082/4885NOD1 1307/4885ALDH1A1 4703/4885
US-20020013310-A1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds STS, ARSA, F12 NOD2 3267/4885NOD1 1135/4885ALDH1A1 1892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.