Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 9/20 | 0.46 |
| ▸ | MMP1 | P03956 | 9/20 | 0.44 |
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | MMP9 | P14780 | 5/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 8/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212175 | 0.73 | MMP7 (0.48) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7210645 | 0.69 | MMP7 (0.44) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6789471 | 0.69 | HDAC6 (0.41) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6790741 | 0.69 | MMP2 (0.40) | MMP7MMP1MMP13MMP9MMP3 | |
| SCHEMBL7215322 | 0.65 | MMP7 (0.51) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6376455 | 0.64 | MMP1 (0.45) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7417303 | 0.63 | MMP1 (0.68) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL8108645 | 0.63 | MMP1 (0.70) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL8441790 | 0.63 | MMP13 (0.55) | MMP7MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7411093 | 0.63 | MMP13 (0.60) | MMP7MMP1MMP13MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037868-B1 | $g(a)-HYDROXY, -AMINO, AND HALO DERIVATIVES OF $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS | UPJOHN CO (US) | 2003-02-05 | — | — | EP | claimed |