Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30676655 | 0.86 | NLRP3 (0.48) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL23218359 | 0.86 | NLRP3 (0.48) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL5568979 | 0.85 | NLRP3 (0.47) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL7358763 | 0.84 | ALDH1A1 (0.56) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL26661046 | 0.84 | CYP4F2 (0.63) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL1558841 | 0.83 | ALDH1A1 (0.51) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL68340 | 0.82 | PKM (0.60) | NLRP3ALDH1A1L3MBTL1PKMCYP4F2 | |
| SCHEMBL3162041 | 0.82 | NLRP3 (0.56) | NLRP3ALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL4579114 | 0.81 | PKM (0.49) | NLRP3ALDH1A1L3MBTL1MAPTPKM | |
| SCHEMBL29853048 | 0.80 | NLRP3 (0.44) | NLRP3ALDH1A1GAAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160217-A | Preparation method of Perampanel, synthetic intermediate and preparation method of degradation impurities | 山东达因海洋生物制药股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| EP-3307739-B1 | NRF2 REGULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-10-07 | — | — | EP | disclosed |
| CN-110028442-B | Simple preparation method of Perampanel | 新发药业有限公司 | 2020-07-17 | — | — | CN | disclosed |
| US-10604509-B2 | Nrf2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-31 | — | — | US | disclosed |
| US-20200071310-A1 | N-ARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-05 | — | — | US | disclosed |
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-30 | — | — | US | disclosed |
| US-20180179187-A1 | Nrf2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2018-06-28 | — | — | US | disclosed |
| US-6586167-B2 | Color forming dye image shows an absorbance for ultraviolet region higher than that for visible region and has a transmission density of 0.3 or more for the region of 360-450 nm. | FUJI PHOTO FILM CO., LTD. (JP) | 2003-07-01 | — | — | US | disclosed |
| US-20020039708-A1 | Method for thermally forming image for plate making and thermally processed image recording material for plate making | FUJI PHOTO FILM CO., LTD. | 2002-04-04 | — | — | US | disclosed |
| EP-0993626-A1 | PHOTOTHERMOGRAPHIC ELEMENT WITH IRIDIUM AND COPPER DOPED SILVER HALIDE GRAINS | EASTMAN KODAK COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| EP-0974073-A2 | CHEMICAL SENSITIZATION OF PHOTOTHERMOGRAPHIC SILVER HALIDE EMULSIONS | EASTMAN KODAK COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998059279-A1 | PHOTOTHERMOGRAPHIC ELEMENT WITH IRIDIUM AND COPPER DOPED SILVER HALIDE GRAINS | EASTMAN KODAK COMPANY (US) | 1998-12-30 | — | — | WO | disclosed |
| WO-1998045754-A2 | CHEMICAL SENSITIZATION OF PHOTOTHERMOGRAPHIC SILVER HALIDE EMULSIONS | EASTMAN KODAK COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179187-A1 | Nrf2 REGULATORS | NFE2L2, KEAP1, NQO1 | NLRP3 2015/4885ALDH1A1 609/4885GAA 2261/4885 |
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | NFE2L2, KEAP1, NQO1 | NLRP3 1404/4885ALDH1A1 372/4885GAA 2920/4885 |
| US-10604509-B2 | Nrf2 regulators | NFE2L2, KEAP1, NQO1 | NLRP3 2015/4885ALDH1A1 609/4885GAA 2261/4885 |
| US-20200071310-A1 | N-ARYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, NQO1, KEAP1 | NLRP3 979/4885ALDH1A1 339/4885GAA 2670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.