Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497979 | 0.90 | LTA4H (0.41) | KCNH2OPRK1DRD2DRD4DRD3 | |
| SCHEMBL7221508 | 0.84 | OPRL1 (0.43) | KCNH2OPRK1DRD2DRD4DRD3 | |
| SCHEMBL7222792 | 0.81 | DRD2 (0.41) | DRD2DRD4DRD3OPRL1 | |
| SCHEMBL7685312 | 0.80 | OPRL1 (0.39) | KCNH2OPRK1DRD2DRD4DRD3 | |
| SCHEMBL7228348 | 0.78 | OPRL1 (0.35) | KCNH2OPRK1DRD2DRD4DRD3 | |
| SCHEMBL7221575 | 0.77 | OPRL1 (0.34) | RIPK2OPRL1 | |
| SCHEMBL7890200 | 0.77 | KDM4E (0.37) | KCNH2OPRK1DRD2DRD4DRD3 | |
| SCHEMBL8174171 | 0.77 | OPRL1 (0.36) | RIPK2OPRL1 | |
| SCHEMBL8184433 | 0.77 | OPRL1 (0.36) | RIPK2OPRL1 | |
| SCHEMBL7229259 | 0.77 | OPRL1 (0.36) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573275-B1 | Insecticidal compositions comprising and to methods of combatting and controlling insect pests therewith. | SYNGENTA LIMITED (GB) | 2003-06-03 | — | — | US | disclosed |
| US-6391883-B1 | INSECTICIDES | SYNGENTA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| US-6207676-B1 | Bicyclic amines | ZENECA LIMITED (GB) | 2001-03-27 | — | — | US | disclosed |
| EP-0828739-A1 | BICYCLIC AMINES AS INSECTICIDES | ZENECA LIMITED (GB) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037494-A1 | BICYCLIC AMINES AS INSECTICIDES | ZENECA LIMITED (GB) | 1996-11-28 | — | — | WO | disclosed |