Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116899 | 0.92 | MMP2 (0.36) | MAPTHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224931 | 0.90 | F2 (0.37) | MMP2MMP7MMP9MMP13KMT2A | |
| SCHEMBL7225149 | 0.90 | HTR4 (0.37) | MAPTHPGDRAB9ASLC6A4 | |
| SCHEMBL7229845 | 0.90 | SLC6A3 (0.42) | RAB9AMMP13SLC6A4 | |
| SCHEMBL7233323 | 0.89 | ESR1 (0.37) | HPGDSLC6A4 | |
| SCHEMBL7232389 | 0.88 | NPC1 (0.36) | RAB9AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231735 | 0.88 | MMP2 (0.36) | MAPTICAM1SELEMMP2MMP7 | |
| SCHEMBL7225066 | 0.88 | SLC6A4 (0.41) | KMT2ASLC6A4 | |
| SCHEMBL7232095 | 0.88 | CHRNA7 (0.34) | HPGDSLC6A4 | |
| SCHEMBL7225381 | 0.87 | HTR3E (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |