Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496643 | 0.93 | RAB9A (0.47) | KDM4ERAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL7328025 | 0.93 | RAB9A (0.47) | KDM4ERAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL5764963 | 0.81 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2HPGDOPRD1 | |
| Hydrochloric Acid SCHEMBL10749720 | 0.79 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2HPGDOPRD1 | |
| SCHEMBL8911057 | 0.71 | ACHE (0.33) | KDM4ERAB9ANPC1ACHE | |
| SCHEMBL2539292 | 0.67 | OPRD1 (0.65) | OPRD1CES2CES1MELK | |
| SCHEMBL31554128 | 0.66 | — | — | |
| SCHEMBL8911535 | 0.66 | HPGD (0.44) | RAB9ANPC1SMN1; SMN2HPGDOPRD1 | |
| SCHEMBL8366194 | 0.66 | HPGD (0.44) | RAB9ANPC1SMN1; SMN2HPGDOPRD1 | |
| SCHEMBL23832799 | 0.66 | OPRD1 (0.44) | KDM4EOPRD1CES2CES1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545037-B2 | Thromboxane A2 (TXA2) receptor and 5HT2 serotonergic receptor antagonists; 3-(6-(((4-chlorophenyl)sulphonyl)amino)-3-((2-(4-methyl-1 -piperazinyl)phenoxy)methyl)-5,6, 7,8-tetrahydro-1-naphthyl)propanoic acid for example | LES LABORATOIRES SERVIER (FR) | 2003-04-08 | — | — | US | disclosed |
| US-6469011-B2 | NITROGEN OXIDE YIELDING AND THROMBOXANE A2 (TXA2) AND SEROTONIN (5HT2) RECEPTOR ANTAGONIST; TREATMENT OF ATHEROTHROMBOTIC CARDIOVASCULAR DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-10-22 | — | — | US | disclosed |
| US-20020137742-A1 | Benzenesulfonamide compounds | LAVIELLE GILBERT (FR) | 2002-09-26 | — | — | US | disclosed |
| EP-1118610-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-08-21 | — | — | EP | disclosed |
| US-20010009915-A1 | New benzenesulfonamide compounds | LES LABORATOIRES SERVIER (FR) | 2001-07-26 | — | — | US | disclosed |
| EP-1118610-A1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010009915-A1 | New benzenesulfonamide compounds | CNR1, CNR2, HTR1A | KDM4E 2862/4885RAB9A 3300/4885NPC1 2907/4885 |
| US-20020137742-A1 | Benzenesulfonamide compounds | CNR1, CNR2, HTR1A | KDM4E 2685/4885RAB9A 3482/4885NPC1 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.