SCHEMBL7227102

SCHEMBL7227102

COc1ccc(C(=O)NS(=O)(=O)c2ccccc2OC(F)(F)F)nc1OC

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.43
ALPL P05186 6/20 0.43
SLC40A1 Q9NP59 1/20 0.42
PTGER4 P35408 1/20 0.41
KAT6A Q92794 1/20 0.40
KCNK3 O14649 1/20 0.40
KCNK9 Q9NPC2 1/20 0.40
AXL P30530 1/20 0.39
SLC22A12 Q96S37 3/20 0.38
PTGS1 P23219 2/20 0.38
PTGS2 P35354 2/20 0.38
ABCC9 O60706 1/20 0.38
ABCC8 Q09428 1/20 0.38
KCNJ11 Q14654 1/20 0.38
KCNJ8 Q15842 1/20 0.38
ALKBH2 Q6NS38 1/20 0.37
ALKBH3 Q96Q83 1/20 0.37
FTO Q9C0B1 1/20 0.37
BRD4 O60885 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7235094 0.90 CTSA (0.42) FBP1ALPLSLC40A1PTGER4KAT6A
SCHEMBL7227903 0.88 FBP1 (0.46) FBP1ALPLSLC40A1PTGER4KAT6A
SCHEMBL7235157 0.81 CA1 (0.46) SLC40A1KAT6APTGS1PTGS2BRD4
SCHEMBL7227108 0.80 FBP1 (0.49) FBP1ALPLSLC40A1PTGER4AXL
SCHEMBL7234926 0.80 ALDH1A1 (0.39) KAT6APTGS1PTGS2ALKBH2ALKBH3
SCHEMBL7235311 0.79 SLC40A1 (0.47) FBP1ALPLSLC40A1PTGER4SLC22A12
SCHEMBL7227192 0.78 FBP1 (0.51) FBP1ALPLSLC40A1PTGER4KCNK3
SCHEMBL30549039 0.76 ALPL (0.47) FBP1ALPLSLC40A1PTGER4KAT6A
SCHEMBL9618654 0.76 FBP1 (0.48) FBP1ALPLSLC40A1PTGER4KAT6A
SCHEMBL7227358 0.75 ALPL (0.44) FBP1ALPLSLC40A1PTGER4SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610853-B1 N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide KUREHA KAGAKU KOGYO K.K. (JP) 2003-08-26 US disclosed
EP-1069112-A1 N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-01-17 EP disclosed