Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 19/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72380 | 1.00 | OPRD1 (0.72) | OPRD1OPRM1OPRK1 | |
| SCHEMBL72676 | 1.00 | OPRD1 (0.72) | OPRD1OPRM1OPRK1 | |
| SCHEMBL12359999 | 0.89 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL12360000 | 0.89 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL12569769 | 0.88 | OPRD1 (0.60) | OPRD1OPRM1OPRK1 | |
| SCHEMBL1142697 | 0.88 | OPRD1 (0.56) | OPRD1OPRM1OPRK1 | |
| SCHEMBL3131262 | 0.85 | OPRD1 (0.79) | OPRD1OPRM1OPRK1 | |
| SCHEMBL12569762 | 0.84 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL84109 | 0.84 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL12359996 | 0.84 | OPRD1 (0.51) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168130-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | claimed |
| US-20070249619-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | claimed |
| CN-1993338-A | Diaryl methyl piperazine derivative and preparation method and application thereof | ASTRAZENECA AB (SE) | 2007-07-04 | — | — | CN | claimed |
| EP-1781631-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | claimed |
| US-20060030569-A1 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | US | claimed |
| WO-2006014133-A1 | DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | claimed |
| US-20120178763-A1 | Method of Treating Anxious Major Depressive Disorder | FREY JOSEPH (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178763-A1 | Method of Treating Anxious Major Depressive Disorder | FREY JOSEPH (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| EP-1562924-A1 | 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| CN-1527820-A | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestional disorders | — | 2004-09-08 | — | — | CN | disclosed |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| WO-2004041802-A1 | 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |
| WO-2004041801-A1 | 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |
| EP-1395567-A1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094794-A1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20120178763-A1 | Method of Treating Anxious Major Depressive Disorder | DRD2, DRD4, HTR1D | OPRD1 22/4885OPRM1 142/4885OPRK1 209/4885 |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | HTR2C, OPRM1, HTR3C | OPRD1 7/4885OPRM1 2/4885OPRK1 8/4885 |
| US-20070249619-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20100168130-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20060030569-A1 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.