Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677282 | 0.89 | POLB (0.34) | LMNAPOLBHTTGRM2GAA | |
| SCHEMBL6675968 | 0.85 | GPR35 (0.39) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6675971 | 0.81 | CACNA1C (0.43) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6678098 | 0.79 | GPR35 (0.39) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6680745 | 0.78 | GAA (0.33) | MEN1KMT2ALMNAPOLBHTT | |
| SCHEMBL7242001 | 0.77 | GPR35 (0.38) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6674967 | 0.77 | GRM2 (0.38) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL6675213 | 0.76 | PNMT (0.39) | GPR35MEN1KMT2ALMNANOS3 | |
| SCHEMBL6676278 | 0.76 | REN (0.37) | GPR35RENMEN1KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL6684653 | 0.75 | PNMT (0.38) | GPR35MEN1KMT2ALMNANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |