Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677280 | 0.88 | LMNA (0.34) | MEN1KMT2ALMNAHTR2CSLC6A4 | |
| SCHEMBL6675968 | 0.83 | GPR35 (0.39) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6676278 | 0.81 | REN (0.37) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6678098 | 0.80 | GPR35 (0.39) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6675971 | 0.79 | CACNA1C (0.43) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL7242006 | 0.77 | GPR35 (0.38) | GPR35RENMEN1KMT2AMAPK1 | |
| SCHEMBL6675210 | 0.77 | PNMT (0.39) | GPR35MEN1KMT2ALMNAMAPT | |
| SCHEMBL6674963 | 0.77 | GLS (0.40) | KMT2ALMNAHTR2CSLC6A4PDK1 | |
| Hydrochloric Acid SCHEMBL6684651 | 0.76 | PNMT (0.38) | GPR35MEN1KMT2ALMNAMAPT | |
| SCHEMBL6678068 | 0.72 | REN (0.36) | RENHTR2CSLC6A4CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |