Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CYP4Z1 | Q86W10 | 10/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.49 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29518725 | 0.79 | CYP4Z1 (0.57) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL16639135 | 0.79 | CYP4Z1 (0.55) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL18833167 | 0.79 | CYP4Z1 (0.53) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL5662069 | 0.79 | CYP4Z1 (0.57) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL8491002 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL1757403 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL1757405 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL9346882 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL238589 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 | |
| SCHEMBL2748 | 0.76 | CYP4Z1 (0.50) | POLBMAPK1ATMCYP4Z1SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245698-B | Nitrogen-containing heterocyclic compound | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-11-30 | — | — | CN | disclosed |
| CN-105263932-A | Heterocyclic compound | TAKEDA PHARMACEUTICAL | 2016-01-20 | — | — | CN | disclosed |
| CN-103373985-B | Heterocyclic compounds and their use | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-10-28 | — | — | CN | disclosed |
| CN-104955824-A | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants | GENENTECH INC | 2015-09-30 | — | — | CN | disclosed |
| CN-103261176-B | 1, 4-oxazepane derivatives | TAKEDA PHARMACEUTICAL | 2015-06-03 | — | — | CN | disclosed |
| CN-104245698-A | Nitrogen-containing heterocyclic compound | TAKEDA PHARMACEUTICAL | 2014-12-24 | — | — | CN | disclosed |
| CN-102123990-B | Heterocyclic compounds and their use | TAKEDA PHARMACEUTICAL | 2014-07-09 | — | — | CN | disclosed |
| CN-103373985-A | Heterocyclic compounds and their use | TAKEDA PHARMACEUTICAL | 2013-10-30 | — | — | CN | disclosed |
| CN-103261176-A | 1, 4-oxazepane derivatives | TAKAEDA CHEMICAL IND LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-101573357-B | Indole compound | TAKAEDA CHEMICAL IND LTD | 2013-01-23 | — | — | CN | disclosed |
| CN-101573357-A | Indole compound | TAKEDA PHARMACEUTICAL (JP) | 2009-11-04 | — | — | CN | disclosed |
| US-6566373-B2 | For therapy of osteoporosis, periodontitis, and arthritis | SMITHKLINE BEECHAM CORPORATION | 2003-05-20 | — | — | US | disclosed |
| EP-1003846-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| US-20020013360-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-01-31 | — | — | US | disclosed |
| EP-1003846-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998050533-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013360-A1 | Protease inhibitors | CTSK, CTSV, CTSS | POLB 3791/4885MAPK1 3027/4885ATM 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.