Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088640 | 0.81 | CA2 (0.32) | CA1CA2TGFBR1MMP2MMP9 | |
| SCHEMBL15251818 | 0.79 | ALDH1A1 (0.48) | CA1CA2ALDH1A1MMP2MMP9 | |
| SCHEMBL8080233 | 0.76 | ITGB3 (0.36) | CA2TGFBR1ALDH1A1MMP2MMP9 | |
| SCHEMBL6976447 | 0.74 | GABRR1 (0.34) | CA1CA2TGFBR1ALDH1A1MMP2 | |
| SCHEMBL7378230 | 0.74 | GABRR1 (0.34) | CA1CA2TGFBR1ALDH1A1MMP2 | |
| SCHEMBL5230591 | 0.73 | CA2 (0.51) | CA2ALDH1A1MMP2MMP9ITGB3 | |
| SCHEMBL7290720 | 0.73 | MMP2 (0.58) | ALDH1A1MMP2MMP9MAPT | |
| SCHEMBL6663128 | 0.72 | ECE1 (0.37) | CA1CA2ALDH1A1 | |
| SCHEMBL8091782 | 0.72 | ITGB3 (0.42) | CA2TGFBR1ITGB3ITGA2B | |
| SCHEMBL30447725 | 0.71 | CA2 (0.42) | CA1CA2ALDH1A1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030171368-A1 | Pyrimidinonesulfamoylureas` | SEITZ WERNER (DE) | 2003-09-11 | — | — | US | disclosed |
| WO-2003066624-A1 | PYRIMIDINONESULFAMOYLUREAS AS INTEGRIN LIGANDS | ABBOTT GMBH & CO. KG (DE) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171368-A1 | Pyrimidinonesulfamoylureas` | ITGB1, ITGA1, ITGAM | CA1 4517/4885CA2 4254/4885TGFBR1 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.