Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27583942 | 0.73 | SIRT6 (0.60) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL6581979 | 0.72 | ENPP2 (0.80) | MAPTALDH1A1LMNAENPP2HTT | |
| SCHEMBL7253850 | 0.72 | MAPT (0.54) | HSD11B1SIRT6MAPTALDH1A1LMNA | |
| SCHEMBL15740402 | 0.72 | ENPP2 (0.42) | SIRT6MAPTLMNAHTR1AENPP2 | |
| SCHEMBL8760113 | 0.71 | SIRT6 (0.56) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL374834 | 0.70 | SIRT6 (0.68) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL2550023 | 0.70 | MAPT (0.72) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL15271381 | 0.69 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL6151230 | 0.69 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL9497275 | 0.68 | HSPB1 (0.59) | MAPTALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613769-B1 | Incubating samples with enzyme inhibitors, then determining complexes formed; medical diagnosis; therapy for allergies and inflammation | Max-Planck-Gesellschaft zur Föderung der Wissenschaften. e.V. (DE) | 2003-09-02 | — | — | US | disclosed |