SCHEMBL7257110

SCHEMBL7257110

CCOC(=O)Nc1cc(Cl)ccc1O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.72
▸ KMT2A Q03164 6/20 0.72
▸ HPGD P15428 1/20 0.72
▸ POLB P06746 1/20 0.58
▸ KCNMA1 Q12791 8/20 0.56
▸ GAA P10253 2/20 0.56
▸ USP2 O75604 1/20 0.56
▸ TP53 P04637 1/20 0.56
▸ MAPT P10636 1/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ TSHR P16473 1/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ CYP1A2 P05177 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ NPC1 O15118 1/20 0.50
▸ RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3787132 0.87 CYP1A2 (0.73) MEN1KMT2AHPGDPOLBGAA
SCHEMBL27861387 0.86 GAA (0.63) MEN1KMT2APOLBGAAUSP2
SCHEMBL8009724 0.85 CYP1A2 (0.75) MEN1KMT2AHPGDPOLBKCNMA1
SCHEMBL9816008 0.84 CYP1A2 (0.58) MEN1KMT2AHPGDPOLBKCNMA1
SCHEMBL7254652 0.83 KCNMA1 (0.61) MEN1KMT2AHPGDPOLBKCNMA1
SCHEMBL7250102 0.83 POLB (0.56) MEN1KMT2AHPGDPOLBKCNMA1
SCHEMBL6290990 0.83 CYP1A2 (0.54) MEN1KMT2AHPGDPOLBGAA
SCHEMBL11025115 0.83 SMN1; SMN2 (0.73) MEN1KMT2AHPGDPOLBGAA
SCHEMBL6333143 0.83 MAPT (0.63) MEN1KMT2AHPGDPOLBGAA
SCHEMBL10740034 0.82 ALDH1A1 (0.56) MEN1KMT2AHPGDPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6635091-B2 Oxidation color dye and coupler L'OREAL S. A. (FR) 2003-10-21 — — US claimed
US-20020178512-A1 Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods L'OREAL SA (FR) 2002-12-05 — — US claimed
US-20010034914-A1 Compositions for the oxidation dyeing of keratinous fibers comprising at least one coupler, and dyeing methods L'OREAL S.A. (FR) 2001-11-01 — — US claimed
US-6635091-B2 Oxidation color dye and coupler L'OREAL S. A. (FR) 2003-10-21 — — US disclosed
US-20020178512-A1 Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods L'OREAL SA (FR) 2002-12-05 — — US disclosed
US-20010034914-A1 Compositions for the oxidation dyeing of keratinous fibers comprising at least one coupler, and dyeing methods L'OREAL S.A. (FR) 2001-11-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034914-A1 Compositions for the oxidation dyeing of keratinous fibers comprising at least one coupler, and dyeing methods KRT18, FH, FGB MEN1 2803/4885KMT2A 1017/4885HPGD 405/4885
US-20020178512-A1 Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods FH, KRT18, CYB5R3 MEN1 4487/4885KMT2A 2099/4885HPGD 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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