Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.49 |
| ▸ | THRB | P10828 | 6/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694690 | 0.80 | RORC (0.56) | RORCTHRBP2RX3P2RX2CYP2D6 | |
| SCHEMBL7258655 | 0.79 | RORC (0.46) | RORCTHRBTHRA | |
| SCHEMBL7263674 | 0.72 | THRB (0.44) | RORCTHRBP2RX3P2RX2CYP2D6 | |
| SCHEMBL6367085 | 0.71 | RORC (0.62) | RORCTHRBCYP2D6ADRA2AADRA1A | |
| SCHEMBL487152 | 0.71 | CYP2D6 (0.67) | RORCTHRBP2RX3P2RX2CYP2D6 | |
| SCHEMBL8062067 | 0.70 | RORC (0.51) | RORCTHRBTHRA | |
| SCHEMBL22959261 | 0.69 | THRB (0.70) | RORCTHRBTHRA | |
| SCHEMBL6818059 | 0.69 | RORC (0.70) | RORCTHRBP2RX3P2RX2THRA | |
| SCHEMBL31179987 | 0.69 | P2RX3 (0.52) | RORCTHRBP2RX3P2RX2CYP2D6 | |
| SCHEMBL14264315 | 0.68 | RORC (0.62) | RORCTHRBP2RX3P2RX2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |