Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA4 | P22459 | 1/20 | 0.37 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.37 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956420 | 0.81 | — | — | |
| SCHEMBL1970312 | 0.78 | KCNA4 (0.39) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL42141 | 0.76 | FFAR3 (0.52) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL7258460 | 0.76 | KCNA4 (0.43) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL16153587 | 0.74 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1FFAR3 | |
| Hydrochloric Acid SCHEMBL15522635 | 0.74 | FFAR3 (0.50) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL19237132 | 0.74 | KCNA4 (0.32) | KCNA4KCNA1KCNAB1 | |
| SCHEMBL7733528 | 0.74 | KCNA4 (0.37) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL1871799 | 0.74 | PKM (0.37) | KCNA4KCNA1KCNAB1FFAR3 | |
| SCHEMBL10579808 | 0.73 | GABRA1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051336-B2 | Regioselective acylation of rapamycin at the C-42 position | SANDOZ (CH) | 2015-06-09 | — | — | US | claimed |
| US-20140081016-A1 | REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION | SANDOZ AG (CH) | 2014-03-20 | — | — | US | claimed |
| EP-2694520-A1 | REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION | Sandoz AG (CH) | 2014-02-12 | — | — | EP | claimed |
| WO-2012131019-A1 | REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION | SANDOZ AG (CH) | 2012-10-04 | — | — | WO | claimed |
| EP-1216251-B1 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | WYETH CORP (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1216251-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | Wyeth (US) | 2002-06-26 | — | — | EP | claimed |
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-08 | — | — | US | claimed |
| US-6277983-B1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-21 | — | — | US | claimed |
| WO-2001023395-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-04-05 | — | — | WO | claimed |
| CN-109689608-B | Novel curcuminoid derivatives and their use as anti-cancer agents | 台湾中国医药大学 | 2022-07-29 | — | — | CN | disclosed |
| US-20220157484-A1 | POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2022-05-19 | — | — | US | disclosed |
| EP-3433225-B1 | NOVEL DERIVATIVES OF CURCUMINOIDS AND USE THEREOF AS AN ANTICANCER AGENT | UNIV CHINA MEDICAL (TW) | 2021-03-17 | — | — | EP | disclosed |
| EP-3433225-B1 | NOVEL DERIVATIVES OF CURCUMINOIDS AND USE THEREOF AS AN ANTICANCER AGENT | UNIV CHINA MEDICAL (TW) | 2021-03-17 | — | — | EP | disclosed |
| US-10787413-B2 | Derivatives of curcuminoids and use thereof as an anticancer agent | CHINA MEDICAL UNIVERSITY (TW) | 2020-09-29 | — | — | US | disclosed |
| WO-2009137448-A2 | CURE ACCELERATORS FOR ANAEROBIC CURABLE COMPOSITIONS | HENKEL CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |
| EP-1216251-B1 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | WYETH CORP (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1216251-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | Wyeth (US) | 2002-06-26 | — | — | EP | disclosed |
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-08 | — | — | US | disclosed |
| US-6277983-B1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-21 | — | — | US | disclosed |
| WO-2001023395-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | RICTOR, MTOR, RPTOR | KCNA4 4514/4885KCNA1 4721/4885KCNAB1 4565/4885 |
| US-20140081016-A1 | REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION | RICTOR, RPTOR, MTOR | KCNA4 2056/4885KCNA1 1999/4885KCNAB1 1615/4885 |
| US-10787413-B2 | Derivatives of curcuminoids and use thereof as an anticancer agent | HPGDS, DHFR, MYC | KCNA4 4307/4885KCNA1 4576/4885KCNAB1 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.