SCHEMBL7258875

SCHEMBL7258875

CNNc1cccc(CN(C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
TSHR P16473 1/20 0.47
NOS1 P29475 3/20 0.45
NOS2 P35228 1/20 0.45
KDM1A O60341 1/20 0.41
RCOR1 Q9UKL0 1/20 0.41
HTR7 P34969 2/20 0.41
ACP1 P24666 3/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
HPGD P15428 1/20 0.39
TAAR1 Q96RJ0 3/20 0.38
HRH3 Q9Y5N1 1/20 0.38
HTR6 P50406 1/20 0.37
PYCR1 P32322 1/20 0.36
KIT P10721 1/20 0.35
PDGFRA P16234 1/20 0.35
KDR P35968 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175219 0.85 TSHR (0.50) ALDH1A1TSHRNOS1NOS2KDM1A
SCHEMBL4200353 0.79 NOS1 (0.49) ALDH1A1TSHRNOS1NOS2KDM1A
SCHEMBL30704883 0.79 NOS1 (0.49) ALDH1A1TSHRNOS1NOS2KDM1A
SCHEMBL16590399 0.79 RAPGEF4 (0.51) ALDH1A1HPGD
SCHEMBL23134330 0.78 NOS1 (0.51) ALDH1A1TSHRNOS1NOS2KDM1A
SCHEMBL989636 0.77 ALDH1A1 (0.67) ALDH1A1TSHRNOS1HTR7CHRNB2
SCHEMBL20027641 0.77 PDK1 (0.46) ALDH1A1TSHRKDM1ARCOR1HTR7
SCHEMBL20027769 0.77 HTR6 (0.47) ALDH1A1NOS1NOS2HTR6
SCHEMBL23133807 0.76 ALDH1A1 (0.45) ALDH1A1TSHRNOS1NOS2KDM1A
SCHEMBL24093147 0.76 ALDH1A1 (0.45) ALDH1A1TSHRNOS1NOS2KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0614898-B1 INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF TORAY INDUSTRIES (JP) 2003-05-07 EP disclosed
US-6291470-B1 DELTA-OPIOID ANTAGONIST HAVING HIGH SELECTIVITY AND ACTIVITY, THAT EXHIBITS IMMUNOSUPPRESSIVE ACTION, ANTIALLERGIC ACTION, ANTI-INFLAMMATORY ACTION AND BRAIN CELL-PROTECTING ACTION TORAY INDUSTRIES, INC. (JP) 2001-09-18 US disclosed
US-6087369-A AN IMMUNOSUPPRESSIVE AGENT, ANTIALLERGIC AGENT, ANTI-INFLAMMATORY AGENT AND BRAIN CELL-PROTECTING AGENT TORAY INDUSTRIES, LTD. (JP) 2000-07-11 US disclosed
EP-0614898-A1 INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 1994-09-14 EP disclosed