Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.44 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27304337 | 0.78 | HSD11B1 (0.45) | — | |
| SCHEMBL4278447 | 0.75 | CHRNB2 (0.49) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11486276 | 0.74 | ALDH1A1 (0.51) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11486228 | 0.74 | CHRNB2 (0.48) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11469767 | 0.73 | CHIT1 (0.60) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11491553 | 0.72 | SIGMAR1 (0.45) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11471258 | 0.71 | ALDH1A1 (0.44) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11479223 | 0.71 | KDM4E (0.44) | KCNH2CHIT1CHIAALDH1A1KDM4E | |
| SCHEMBL11369857 | 0.70 | CHRNB2 (0.54) | KCNH2CHI3L1HRH3 | |
| SCHEMBL8273684 | 0.70 | CHI3L1 (0.46) | KCNH2CHIT1CHIAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299357-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001098273-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |