SCHEMBL726663

SCHEMBL726663

Cc1cc(C)cc(-c2cc(O)ccc2Sc2ccc(O)cc2-c2cc(C)cc(C)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CNR1 P21554 3/20 0.37
CNR2 P34972 3/20 0.37
ESR2 Q92731 7/20 0.36
ESR1 P03372 6/20 0.36
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
ACHE P22303 2/20 0.34
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28502601 0.79 ESR1 (0.48) HSD17B10ESR2ESR1HSD17B1HSD17B2
SCHEMBL28485937 0.78 CALCRL (0.40) MEN1KMT2ALMNATP53GAA
SCHEMBL1860042 0.78 ALDH1A1 (0.44) LMNATP53GAAMAPTHPGD
SCHEMBL27658836 0.78 ALDH1A1 (0.44) MEN1KMT2AGAAALDH1A1CNR1
SCHEMBL11128246 0.77 RXRA (0.38) MEN1KMT2AGAAMAPTHPGD
SCHEMBL9297510 0.76 ALOX5 (0.57) MEN1KMT2AMAPTHPGDHSD17B10
SCHEMBL27619639 0.75 ALOX5 (0.56) ALDH1A1CNR1CNR2ESR2ESR1
SCHEMBL8999895 0.74 HSD17B1 (0.52) LMNAHSD17B10ALDH1A1ESR2ESR1
SCHEMBL5887732 0.74 BRD9 (0.41) MEN1KMT2ALMNATP53GAA
SCHEMBL726424 0.73 CNR1 (0.40) ALDH1A1CNR1CNR2ESR2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 272 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1660560-B1 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-03-23 EP claimed
JP-4768635-B2 2011-09-07 JP claimed
EP-1546249-B1 FLAME RETARDANT RESINOUS COMPOSITIONS AND METHOD SABIC INNOVATIVE PLASTICS IP (NL) 2011-03-16 EP claimed
US-7714095-B2 Phase transfer catalyzed method for preparation of polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-05-11 US claimed
JP-2009521548-A 2009-06-04 JP claimed
EP-1660556-B1 COPOLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2009-05-13 EP claimed
EP-1966320-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES General Electric Company (US) 2008-09-10 EP claimed
EP-1963433-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS General Electric Company (US) 2008-09-03 EP claimed
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP claimed
EP-1960470-A2 FOOD SERVICE ARTICLES OF MANUFACTURE COMPRISING HIGH TEMPERATURE POLYMERS General Electric Company (US) 2008-08-27 EP claimed
WO-2005021477-A2 METHOD FOR MAKING SALTS OF HYDROXY-SUBSTITUTED HYDROCARBONS GENERAL ELECTRIC COMPANY (US) 2005-03-10 WO claimed
US-20050049390-A1 Phase transfer catalyzed method for preparation of polyetherimides GENERAL ELECTRIC COMPANY 2005-03-03 US claimed
US-20050049439-A1 Method for making salts hydroxy-substituted hydrocarbons GENERAL ELECTRIC COMPANY 2005-03-03 US claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed
US-6844071-B1 Multilayer articles comprising polycarbonate and polypropylene and method for their preparation GENERAL ELECTRIC COMPANY (US) 2005-01-18 US claimed
US-6713598-B2 FLAME RETARDANT WITH SPECIFIED MOLECULAR WEIGHT AND SOFTENING TEMPERATURE; REACTING PHOSPHORUS OXYHALIDE WITH HYDROXYAROMATIC COMPOUND, REACTING ARYLDIHALOPHOSPHATE WITH DIHYDROXYAROMATIC, THEN WITH HYDROXYAROMATIC GENERAL ELECTRIC COMPANY 2004-03-30 US claimed
US-20040044134-A1 METHOD TO MAKE A SOLID POLYMERIC PHOSPHATE AND RESINOUS COMPOSITIONS CONTAINING IT GENERAL ELECTRIC COMPANY 2004-03-04 US claimed
WO-2004016685-A2 FLAME RETARDANT RESINOUS COMPOSITIONS AND METHOD GENERAL ELECTRIC COMPANY (US) 2004-02-26 WO claimed
US-20040034132-A1 Flame retardant resinous compositions and method GENERAL ELECTRIC COMPANY 2004-02-19 US claimed
US-20040014934-A1 Method for the production of polyestercarbonates GENERAL ELECTRIC COMPANY 2004-01-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050049439-A1 Method for making salts hydroxy-substituted hydrocarbons HDHD5, SHH, HAAO MEN1 892/4885KMT2A 639/4885LMNA 1647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.