Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536153 | 0.81 | CTSD (0.55) | MMP2 | |
| SCHEMBL8536393 | 0.80 | CTSD (0.52) | MMP2 | |
| SCHEMBL23615410 | 0.78 | MMP2 (0.61) | MMP2ITGB3ITGA2B | |
| SCHEMBL25674461 | 0.78 | MMP2 (0.61) | MMP2ITGB3ITGA2B | |
| SCHEMBL8853787 | 0.78 | REN (0.50) | — | |
| SCHEMBL7279553 | 0.77 | HTT (0.48) | ENPP2 | |
| SCHEMBL11648896 | 0.76 | ITGB3 (0.69) | MMP2ITGB3ITGA2BFAAH | |
| SCHEMBL13956896 | 0.72 | HDAC3 (0.58) | MMP2ITGB3ITGA2B | |
| SCHEMBL8863136 | 0.71 | MMP2 (0.59) | MMP2ITGB3ITGA2B | |
| D-Phenylalanine SCHEMBL11649893 | 0.71 | ITGB3 (0.62) | MMP2ITGB3ITGA2BFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |