Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090551 | 0.91 | RARA (0.41) | KDM4ERARARARBRARGNR1H2 | |
| SCHEMBL7277331 | 0.90 | F10 (0.40) | KDM4ERARARARBRARGF10 | |
| SCHEMBL8088448 | 0.90 | RARA (0.32) | RARARARBRARGF10 | |
| SCHEMBL7268034 | 0.88 | ALOX5 (0.40) | RARARARBRARGF10NPC1 | |
| SCHEMBL8088450 | 0.87 | RARA (0.32) | RARARARBRARG | |
| SCHEMBL7276973 | 0.86 | F10 (0.33) | RARARARBRARGF10 | |
| SCHEMBL8085176 | 0.85 | MAOA (0.42) | F10NPC1RAB9APDK2MEN1 | |
| SCHEMBL8204761 | 0.85 | S100A4 (0.36) | S100A4KDM4ENR1H2NR1H3F10 | |
| SCHEMBL10697122 | 0.85 | MAPT (0.34) | S100A4KDM4ERARARARBRARG | |
| SCHEMBL7277024 | 0.85 | ALDH1A1 (0.42) | KDM4ERAB9AMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-5391751-A | Hypotensive, antiarrhythmia, antiasthmatic agents | RED BALLOON INVESTMENT LIMITED (JE) | 1995-02-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5043352-A | Chroman derivatives for the treatment of depressive states | SANOFI (FR) | 1991-08-27 | — | — | US | disclosed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |