Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275535 | 0.91 | CCR3 (0.43) | DRD2HTR1ANAMPTHDAC8HDAC6 | |
| SCHEMBL7281678 | 0.89 | HTR1A (0.42) | DRD2HTR1ANAMPTDRD3HDAC8 | |
| SCHEMBL7284443 | 0.88 | DRD2 (0.38) | DRD2NAMPTDRD3HDAC8HDAC6 | |
| SCHEMBL7284718 | 0.86 | HTR1A (0.42) | DRD2HTR1ANAMPTDRD3DRD4 | |
| SCHEMBL7280648 | 0.83 | HTR1A (0.41) | DRD2HTR1ADRD4 | |
| SCHEMBL7280539 | 0.81 | SIGMAR1 (0.44) | DRD2HTR1ANAMPTDRD3MAOA | |
| SCHEMBL7274964 | 0.79 | CCR3 (0.44) | HTR1ANAMPTHDAC6DRD4MAOA | |
| Methyl Alcohol SCHEMBL8879759 | 0.79 | HTR1A (0.40) | DRD2HTR1ANAMPTDRD3HDAC6 | |
| SCHEMBL7278834 | 0.78 | HTR1A (0.39) | HTR1ANAMPTHDAC6CHRM3 | |
| SCHEMBL7273369 | 0.78 | MAOA (0.38) | DRD2HTR1ANAMPTDRD3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |