Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949805 | 0.81 | SIGMAR1 (0.50) | PLD1SLC6A4HPGDHTR3EHTR3B | |
| SCHEMBL1631738 | 0.78 | CHRNB2 (0.47) | SLC6A4JUNNFKB1CYP3A4CYP2D6 | |
| SCHEMBL27811539 | 0.72 | HTR6 (0.40) | HPGDSIGMAR1MAPTCYP2C9CYP2C19 | |
| SCHEMBL12431850 | 0.71 | ADRB2 (0.70) | PLD1ADRB2NCF1HTR3EHTR3B | |
| SCHEMBL3588114 | 0.69 | PLD1 (0.48) | PLD1ADRB2NCF1SLC6A4CYP3A4 | |
| SCHEMBL9080474 | 0.69 | JUN (0.46) | PLD1ADRB2NCF1JUNNFKB1 | |
| SCHEMBL7503359 | 0.69 | ADRB1 (0.53) | SLC6A4ADRB1HTR3ASIGMAR1ALDH1A1 | |
| SCHEMBL3593807 | 0.69 | PLD1 (0.53) | PLD1ADRB2NCF1SLC6A4CYP3A4 | |
| SCHEMBL11472516 | 0.68 | JUN (0.58) | JUNNFKB1HPGDALDH1A1MAPT | |
| SCHEMBL11472515 | 0.68 | JUN (0.58) | JUNNFKB1HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |