Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294460 | 0.95 | ALOX15 (0.54) | ALOX15HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7299907 | 0.77 | ALOX15 (0.46) | ALOX15HTTCASP1 | |
| SCHEMBL7319434 | 0.72 | NPC1 (0.49) | KMT2A | |
| SCHEMBL10587659 | 0.72 | HTR2A (0.47) | ALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL13196414 | 0.71 | SIGMAR1 (0.59) | HDAC1HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL1915970 | 0.70 | CPA3 (0.56) | PKM | |
| SCHEMBL8895410 | 0.69 | LAP3 (0.50) | PKM | |
| SCHEMBL902140 | 0.69 | ABCB1 (0.47) | ALDH1A1KMT2A | |
| SCHEMBL7293697 | 0.69 | LMNA (0.55) | KMT2A | |
| SCHEMBL22170874 | 0.68 | ALDH1A1 (0.44) | HDAC1HDAC2HDAC8HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401722-A | Peptide analogues | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-03-28 | — | — | US | disclosed |
| EP-0501280-A2 | Renin-inhibiting peptide analogues | MERCK PATENT GmbH (DE) | 1992-09-02 | — | — | EP | disclosed |
| EP-0446485-A2 | Peptide analogues with renininhibiting activity | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |