Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 8/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333172 | 0.86 | CTSK (0.59) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL7333168 | 0.86 | CTSK (0.59) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL2066047 | 0.86 | CTSK (0.54) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL11808814 | 0.86 | PSMB1 (0.53) | PSMB1CTSKPSMB8PSMB5CTSS | |
| SCHEMBL7736831 | 0.85 | KYNU (0.60) | PSMB1CTSKPSMB8PSMB5CTSS | |
| SCHEMBL5181237 | 0.85 | KYNU (0.60) | PSMB1CTSKPSMB8PSMB5CTSS | |
| SCHEMBL7688519 | 0.85 | PSMB1 (0.57) | PSMB1CTSKPSMB8PSMB5CTSS | |
| SCHEMBL7728708 | 0.84 | CTSL (0.55) | CTSKCTSSCTSLCTSBCASP1 | |
| SCHEMBL8078067 | 0.83 | PSMB1 (0.56) | PSMB1CTSKPSMB8PSMB5CTSS | |
| SCHEMBL16494690 | 0.83 | SIRT2 (0.53) | CTSKCTSSCTSLECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583248-A | Amino acid derivatives having antiviral activity | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0512343-B1 | Amino acid derivatives and their use as anti-viral agents | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | EP | disclosed |
| US-5430041-A | Amino acid derivatives having antiviral activity | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0512343-A2 | Amino acid derivatives and their use as anti-viral agents | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |