Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GRK3 | P35626 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305182 | 0.92 | HRH3 (0.46) | GPR119ADRB2HTR1AADRB1SLC22A1 | |
| SCHEMBL7329284 | 0.88 | GPR119 (0.45) | GPR119ADRB2HTR1AADRB1SLC22A1 | |
| SCHEMBL7303501 | 0.86 | ADRB1 (0.49) | GPR119ADRB2HTR1AADRB1CYP1A2 | |
| SCHEMBL7300352 | 0.84 | ADRB1 (0.51) | GPR119ADRB2HTR1AADRB1GRK3 | |
| SCHEMBL7295783 | 0.83 | PDE3A (0.43) | GPR119ADRB2HTR1AADRB1SLC6A4 | |
| SCHEMBL9687380 | 0.82 | GPR119 (0.39) | GPR119ADRB2HTR1AADRB1GRK3 | |
| SCHEMBL7305054 | 0.81 | SLC22A1 (0.39) | GPR119ADRB2HTR1AADRB1SLC22A1 | |
| SCHEMBL7305060 | 0.81 | PDE3B (0.43) | GPR119ADRB2HTR1AADRB1SLC22A1 | |
| SCHEMBL7328370 | 0.80 | HRH3 (0.47) | ADRB2HTR1AADRB1SLC22A1HTR2A | |
| SCHEMBL7335463 | 0.78 | HRH3 (0.54) | GPR119ADRB2ADRB1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |