Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | GRK3 | P35626 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686104 | 0.93 | HRH3 (0.43) | GRK3PDE4BPDE3APDE4APDE4C | |
| SCHEMBL7300352 | 0.87 | ADRB1 (0.51) | GPR119GRK3PDE4BPDE3APDE4A | |
| SCHEMBL7303501 | 0.84 | ADRB1 (0.49) | GPR119ADRB3ADRB2ADRB1HTR1A | |
| SCHEMBL7329284 | 0.84 | GPR119 (0.45) | GPR119ADRB3ADRB2ADRB1HTR1A | |
| SCHEMBL9687154 | 0.83 | GPR119 (0.35) | GPR119PDE4BPDE3APDE4APDE4C | |
| SCHEMBL9687171 | 0.83 | PDE3B (0.41) | GPR119PDE4BPDE3APDE4APDE4C | |
| SCHEMBL7303255 | 0.82 | GPR119 (0.42) | GPR119GRK3PDE4BPDE3APDE4A | |
| SCHEMBL7295783 | 0.81 | PDE3A (0.43) | GPR119GRK3PDE4BPDE3APDE4A | |
| SCHEMBL7306614 | 0.79 | ADRB1 (0.52) | GRK3PDE4BPDE3APDE4APDE4C | |
| SCHEMBL7328370 | 0.76 | HRH3 (0.47) | ADRB3ADRB2ADRB1HRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |