Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 7/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7304911 | 1.00 | NOTUM (0.47) | NOTUMCHRM3CHRM2CHRM1KDM4E | |
| Fumaric Acid SCHEMBL7296355 | 0.96 | NOTUM (0.46) | NOTUMCHRM3CHRM2CHRM1KDM4E | |
| Maleic Acid SCHEMBL7296350 | 0.96 | NOTUM (0.46) | NOTUMCHRM3CHRM2CHRM1KDM4E | |
| SCHEMBL7304610 | 0.82 | NOTUM (0.52) | NOTUMCHRM3CHRM2CHRM1 | |
| SCHEMBL7305951 | 0.70 | NOTUM (0.55) | NOTUMCHRM3CHRM2CHRM1 | |
| SCHEMBL19750130 | 0.70 | NOTUM (0.68) | NOTUM | |
| SCHEMBL17446885 | 0.66 | NOTUM (1.00) | NOTUMKDM4E | |
| SCHEMBL4917429 | 0.66 | HTR3E (0.56) | CHRM3CHRM2CHRM1 | |
| SCHEMBL4917433 | 0.66 | HTR3E (0.56) | CHRM3CHRM2CHRM1 | |
| SCHEMBL14580884 | 0.65 | OPRL1 (0.56) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403882-A2 | Indole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-27 | — | — | EP | disclosed |