Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 9/20 | 0.44 |
| ▸ | CTSG | P08311 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 2/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306959 | 0.87 | PAM (0.47) | PSMB5ACE | |
| SCHEMBL7301739 | 0.83 | ALDH1A1 (0.43) | PSMB5CTSGCMA1PSMB1PSMB2 | |
| SCHEMBL7305034 | 0.83 | PSMB5 (0.53) | PSMB5CTSGCMA1PSMB1PSMB2 | |
| SCHEMBL7305024 | 0.83 | PSMB5 (0.53) | PSMB5CTSGCMA1PSMB1PSMB2 | |
| SCHEMBL7306865 | 0.82 | PSMB1 (0.56) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7311946 | 0.82 | ATM (0.52) | ACE | |
| SCHEMBL7300595 | 0.79 | PSMB1 (0.52) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7431424 | 0.79 | CTSL (0.48) | — | |
| SCHEMBL7432833 | 0.79 | GGT1 (0.47) | PSMB5ACE | |
| SCHEMBL7312132 | 0.78 | CTSG (0.43) | PSMB5CTSGCMA1PSMB1PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |