Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.58 |
| ▸ | PPARA | Q07869 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295502 | 0.92 | PPARG (0.63) | PPARGPPARAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7296334 | 0.86 | PPARG (0.56) | PPARGPPARAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7294958 | 0.73 | QDPR (0.55) | SIGMAR1 | |
| SCHEMBL7230184 | 0.73 | MAOA (0.62) | KDM4EALDH1A1SMN1; SMN2HTR5APOLB | |
| SCHEMBL7564110 | 0.72 | KDM4E (0.82) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7698158 | 0.71 | PPARG (0.61) | PPARGPPARASIGMAR1S1PR1S1PR3 | |
| SCHEMBL7303423 | 0.70 | QDPR (0.51) | ALDH1A1SIGMAR1 | |
| SCHEMBL7305701 | 0.70 | QDPR (0.55) | SIGMAR1 | |
| SCHEMBL9825271 | 0.70 | HTR1A (0.52) | PPARGPPARASIGMAR1S1PR1S1PR3 | |
| SCHEMBL7228164 | 0.69 | MAOA (0.57) | KDM4EALDH1A1SMN1; SMN2HTR5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149817-A | Psychotropic agents | SHIONOGI & CO., LTD. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445701-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |