Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 5/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778660 | 0.80 | MME (0.51) | MAPT | |
| SCHEMBL7307409 | 0.76 | LAP3 (0.42) | KDM5AKDM5BKDM4C | |
| SCHEMBL10779210 | 0.71 | CYP1A2 (0.49) | KDM5BKDM4CNR3C2KDM4EKDM5C | |
| SCHEMBL7297368 | 0.71 | KDM5A (0.44) | KDM5AKDM5BKDM4CKDM4DNR3C2 | |
| SCHEMBL7301495 | 0.70 | MME (0.60) | KDM4E | |
| SCHEMBL7300179 | 0.69 | KDM5B (0.45) | KDM5BKDM4CMAPTGSK3BKDM4E | |
| SCHEMBL7303824 | 0.69 | LNPEP (0.43) | KDM5AKDM5BKDM4CMAPTGSK3B | |
| SCHEMBL3491650 | 0.69 | RAB9A (0.61) | KDM5AKDM5BKDM4CKDM4DNR3C2 | |
| SCHEMBL29409190 | 0.69 | RAB9A (0.61) | KDM5AKDM5BKDM4CKDM4DNR3C2 | |
| SCHEMBL7303694 | 0.68 | LNPEP (0.57) | KDM5BKDM4CNR3C2KDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |