Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.46 |
| ▸ | MMP13 | P45452 | 8/20 | 0.41 |
| ▸ | MMP14 | P50281 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | MMP8 | P22894 | 4/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MMP10 | P09238 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ATF4 | P18848 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311858 | 0.91 | MMP1 (0.45) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7300368 | 0.90 | MMP1 (0.40) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7301981 | 0.86 | MMP1 (0.61) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7304251 | 0.82 | MMP1 (0.47) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7299168 | 0.81 | LMNA (0.39) | MMP1MMP13MMP2ALDH1A1HPGD | |
| SCHEMBL7309991 | 0.80 | LMNA (0.41) | MMP1MMP13MMP2ALDH1A1HPGD | |
| SCHEMBL7302785 | 0.78 | MMP1 (0.76) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7306527 | 0.77 | NPC1 (0.36) | MMP1MMP13MMP14MMP2MMP9 | |
| SCHEMBL7307984 | 0.77 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1 | |
| SCHEMBL7303599 | 0.76 | MMP1 (0.49) | MMP1MMP13MMP14MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |