Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.35 |
| ▸ | MMP13 | P45452 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 3/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300368 | 0.88 | MMP1 (0.40) | NPC1RAB9AS1PR2MMP13MMP1 | |
| SCHEMBL7305971 | 0.86 | MMP1 (0.40) | MMP13MMP1MMP9MMP3MMP8 | |
| SCHEMBL7302125 | 0.82 | ALDH1A1 (0.39) | MMP13MMP1SCN9ALTA4H | |
| SCHEMBL7299168 | 0.81 | LMNA (0.39) | NPC1RAB9AMMP13MMP1MMP2 | |
| SCHEMBL7309991 | 0.80 | LMNA (0.41) | RAB9AMMP13MMP1MMP2LTA4H | |
| SCHEMBL7311907 | 0.79 | P2RX7 (0.41) | NPC1RAB9AS1PR2 | |
| SCHEMBL7299039 | 0.78 | MMP1 (0.46) | MMP13MMP1MMP9MMP3MMP8 | |
| SCHEMBL7311858 | 0.78 | MMP1 (0.45) | MMP13MMP1MMP9MMP3MMP8 | |
| SCHEMBL7308043 | 0.77 | MMP1 (0.46) | MMP13MMP1MMP9MMP3MMP8 | |
| SCHEMBL7307984 | 0.77 | ALDH1A1 (0.39) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |