Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299168 | 0.87 | LMNA (0.39) | ALDH1A1NPC1RAB9ALMNAPOLB | |
| SCHEMBL7309991 | 0.86 | LMNA (0.41) | ALDH1A1RAB9ALMNAGAAMAPT | |
| SCHEMBL7305235 | 0.85 | MMP1 (0.47) | NPC1TP53 | |
| SCHEMBL7310236 | 0.80 | HSD11B1 (0.44) | ALDH1A1NPC1MTNR1AMTNR1BTP53 | |
| SCHEMBL7311858 | 0.78 | MMP1 (0.45) | ALDH1A1LMNAGAAMAPTL3MBTL1 | |
| SCHEMBL7308043 | 0.77 | MMP1 (0.46) | ALDH1A1L3MBTL1 | |
| SCHEMBL7300368 | 0.77 | MMP1 (0.40) | ALDH1A1NPC1RAB9A | |
| SCHEMBL7306527 | 0.77 | NPC1 (0.36) | NPC1RAB9A | |
| SCHEMBL7304471 | 0.75 | MMP13 (0.45) | — | |
| SCHEMBL7862221 | 0.72 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |