Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313653 | 0.91 | EBP (0.43) | CYP3A4ABCB1ADRA1DADRA1AADRA1B | |
| SCHEMBL7311139 | 0.91 | EBP (0.43) | CYP3A4ABCB1ADRA1DADRA1AADRA1B | |
| SCHEMBL7315211 | 0.90 | POLB (0.39) | CYP3A4ABCB1ADRA1DADRA1AADRA1B | |
| SCHEMBL7309649 | 0.88 | MTNR1A (0.43) | CYP3A4GPR139ABCB1ADRA1AOPRM1 | |
| SCHEMBL7314600 | 0.84 | GPR139 (0.39) | CYP3A4GPR139ABCB1ADRA1DADRA1A | |
| SCHEMBL7309023 | 0.83 | CYP3A4 (0.42) | CYP3A4ABCB1CYP3A5EBPSIGMAR1 | |
| SCHEMBL7309344 | 0.80 | L3MBTL1 (0.37) | CYP3A4ADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL7313591 | 0.79 | CCR1 (0.39) | ADRA1DADRA1AADRA1BTACR1HDAC6 | |
| SCHEMBL7314922 | 0.75 | EBP (0.43) | CYP3A4ABCB1EBPSIGMAR1L3MBTL1 | |
| SCHEMBL7305541 | 0.74 | EBP (0.43) | CYP3A4ABCB1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041064-A2 | N-substituted alpha aminoacid amides as calcium channel modulators | ELI LILLY AND COMPANY LIMITED (GB) | 2000-10-04 | — | — | EP | disclosed |
| EP-0805147-A1 | Novel N-substituted alpha aminoacid amides as calcium channel modulators | LILLY INDUSTRIES LIMITED (GB) | 1997-11-05 | — | — | EP | disclosed |