Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.51 |
| ▸ | MMP1 | P03956 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 4/20 | 0.51 |
| ▸ | MMP7 | P09237 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303615 | 0.90 | SCN5A (0.49) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL7301926 | 0.88 | HDAC1 (0.43) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL7308120 | 0.81 | OPRK1 (0.47) | SCN5ASCN9AHDAC1HDAC6HDAC3 | |
| SCHEMBL7311907 | 0.79 | P2RX7 (0.41) | HDAC1HDAC6HDAC3HDAC2NPC1 | |
| SCHEMBL8423285 | 0.78 | SCN5A (0.47) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL7308041 | 0.78 | RORC (0.44) | SCN5ASCN9AHDAC1HDAC6HDAC3 | |
| SCHEMBL8315425 | 0.75 | OPRD1 (0.54) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL12050040 | 0.74 | HTT (0.49) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL12050043 | 0.74 | SCN5A (0.50) | MMP9MMP1MMP3MMP7MMP2 | |
| SCHEMBL2472933 | 0.73 | CHRM5 (0.50) | SCN5ASCN9ANPC1GRIN2BAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |