Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195247 | 0.81 | POLB (0.65) | HTR1APOLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7750879 | 0.80 | PGR (0.55) | PARP1HTR1ADRD2HTR2ADAO | |
| SCHEMBL8205213 | 0.80 | PER2 (0.49) | HTR2AALDH1A1TSHRMAPK1HTT | |
| SCHEMBL6028786 | 0.78 | PGR (0.60) | PARP1HTR1ADRD2HTR2ADAO | |
| SCHEMBL29528989 | 0.78 | PGR (0.60) | PARP1HTR1ADRD2HTR2ADAO | |
| SCHEMBL7305582 | 0.77 | HTR1A (0.50) | PARP1HTR1ADRD2HTR2APOLB | |
| SCHEMBL7298333 | 0.77 | ALDH1A1 (0.55) | PARP1HTR1ADRD2HTR2ADAO | |
| SCHEMBL7650175 | 0.77 | PARP1 (0.50) | PARP1HTR1ADRD2HTR2APOLB | |
| SCHEMBL7649804 | 0.76 | HTR1A (0.49) | PARP1HTR1ADRD2HTR2APOLB | |
| SCHEMBL6295463 | 0.76 | PARP1 (0.50) | PARP1HTR1ADRD2HTR2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |