Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 8/20 | 0.41 |
| ▸ | MMP12 | P39900 | 8/20 | 0.41 |
| ▸ | MMP8 | P22894 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 7/20 | 0.41 |
| ▸ | MMP14 | P50281 | 7/20 | 0.41 |
| ▸ | MMP16 | P51512 | 7/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | MMP3 | P08254 | 5/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323459 | 0.91 | LMNA (0.41) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7317729 | 0.91 | RAPGEF4 (0.43) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7312522 | 0.88 | MMP13 (0.46) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7322659 | 0.84 | MMP2 (0.47) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7323700 | 0.84 | RAPGEF4 (0.48) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7323861 | 0.84 | MMP2 (0.41) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7317696 | 0.83 | LMNA (0.42) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7316126 | 0.81 | TAS2R14 (0.45) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7318612 | 0.81 | MMP2 (0.39) | RAPGEF4MMP2MMP12MMP8MMP13 | |
| SCHEMBL7315652 | 0.81 | MMP2 (0.49) | MMP2MMP12MMP8MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |