Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP16 | P51512 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315181 | 0.83 | LMNA (0.42) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL7311423 | 0.79 | KDM4E (0.43) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL7323234 | 0.76 | MMP1 (0.44) | LMNASMN1; SMN2ALDH1A1MMP9MMP13 | |
| SCHEMBL15417550 | 0.72 | PKM (0.72) | RAPGEF4ALDH1A1TP53GAAMAPT | |
| SCHEMBL7314106 | 0.72 | LMNA (0.43) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL7317781 | 0.70 | RAPGEF4 (0.47) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL7317121 | 0.70 | LMNA (0.42) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL7316366 | 0.70 | MMP13 (0.42) | ALDH1A1PKMNPSR1MMP2MMP9 | |
| SCHEMBL6534945 | 0.69 | FFAR4 (0.56) | LMNASMN1; SMN2RAPGEF4ALDH1A1TP53 | |
| SCHEMBL34468649 | 0.68 | GAA (0.61) | SMN1; SMN2RAPGEF4ALDH1A1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |