Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP16 | P51512 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311423 | 0.92 | KDM4E (0.43) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL7315181 | 0.78 | LMNA (0.42) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL7316231 | 0.78 | MMP1 (0.44) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7311630 | 0.70 | LMNA (0.51) | MMP13MMP9MMP1MMP12MMP2 | |
| SCHEMBL7311811 | 0.69 | MMP9 (0.42) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL7323234 | 0.69 | MMP1 (0.44) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7322302 | 0.68 | MMP9 (0.42) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL7316400 | 0.68 | MMP9 (0.54) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL27529783 | 0.67 | MMP9 (0.62) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL8962292 | 0.66 | POLB (0.68) | MMP13MMP9MMP12MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |