Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 9/20 | 0.42 |
| ▸ | MMP8 | P22894 | 9/20 | 0.42 |
| ▸ | MMP12 | P39900 | 9/20 | 0.42 |
| ▸ | MMP13 | P45452 | 9/20 | 0.42 |
| ▸ | MMP14 | P50281 | 9/20 | 0.42 |
| ▸ | MMP16 | P51512 | 9/20 | 0.42 |
| ▸ | MMP9 | P14780 | 8/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 5/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311423 | 0.87 | KDM4E (0.43) | LMNAMMP2MMP8MMP12MMP13 | |
| SCHEMBL7311630 | 0.83 | LMNA (0.51) | LMNAMMP2MMP8MMP12MMP13 | |
| SCHEMBL7323234 | 0.81 | MMP1 (0.44) | LMNAMMP13MMP9KDM4EMMP1 | |
| SCHEMBL7316366 | 0.78 | MMP13 (0.42) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7316231 | 0.73 | MMP1 (0.44) | LMNAMMP13MMP9PKMKDM4E | |
| SCHEMBL7316400 | 0.71 | MMP9 (0.54) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7317524 | 0.70 | NAMPT (0.53) | MMP13MMP9MMP1ADAM17GAA | |
| SCHEMBL7316532 | 0.68 | ALDH1A1 (0.44) | LMNAMMP2MMP8MMP12MMP13 | |
| SCHEMBL5838605 | 0.65 | KDM4E (0.47) | PKMKDM4EGAAHSD17B10HPGD | |
| SCHEMBL9390270 | 0.65 | PKM (0.70) | PKMGAARAPGEF4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |