Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.38 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14360428 | 0.91 | TRPA1 (0.59) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| Ethylenediamine SCHEMBL14353963 | 0.80 | KDM4E (0.48) | LMNAALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9294948 | 0.77 | TRPA1 (0.55) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| SCHEMBL2799841 | 0.77 | ALDH1A1 (0.44) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| Thymol SCHEMBL11578070 | 0.77 | LMNA (0.70) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| Ethylenediamine SCHEMBL14354263 | 0.77 | GRM1 (0.41) | SRCMEN1KMT2ANPSR1TDP1 | |
| Hydrochloric Acid SCHEMBL1774596 | 0.76 | TRPA1 (0.42) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| Ethylenediamine SCHEMBL544736 | 0.75 | TSHR (0.42) | ALDH1A1MEN1KMT2AHPGDHRH1 | |
| SCHEMBL11529752 | 0.75 | LMNA (0.57) | TRPA1CHRM1LMNASLC6A2ADRA1A | |
| SCHEMBL28238190 | 0.75 | TRPA1 (0.62) | TRPA1CHRM1LMNASLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191431-B1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORP (US) | 2023-03-08 | — | — | EP | claimed |
| US-20170283334-A1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORPORATION (US) | 2017-10-05 | — | — | US | claimed |
| EP-3191431-B1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORP (US) | 2023-03-08 | — | — | EP | disclosed |
| US-10974059-B2 | Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field | NANOBACTERIE (FR) | 2021-04-13 | — | — | US | disclosed |
| US-10407353-B2 | Micronutrient fertilizer | SUN CHEMICAL CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190201704-A1 | TREATMENT OF CANCER OR TUMORS INDUCED BY THE RELEASE OF HEAT GENERATED BY VARIOUS CHAINS OF MAGNETOSOMES EXTRACTED FROM MAGNETOTACTIC BACTERIA AND SUBMITTED TO AN ALTERNATING MAGNETIC FIELD | NANOBACTERIE (FR) | 2019-07-04 | — | — | US | disclosed |
| US-10252073-B2 | Treatment of cancer or tumor induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field | NANOBACTERIE (FR) | 2019-04-09 | — | — | US | disclosed |
| US-10238886-B2 | Treatment of cancer or tumors induced by the release of heat generated by various chains of magnetosomes extracted from magnetotactic bacteria and submitted to an alternating magnetic field | NANOBACTERIE (FR) | 2019-03-26 | — | — | US | disclosed |
| US-20170283334-A1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORPORATION (US) | 2017-10-05 | — | — | US | disclosed |
| US-20170157253-A1 | TREATMENT OF CANCER OR TUMOR INDUCED BY THE RELEASE OF HEAT GENERATED BY VARIOUS CHAINS OF MAGNETOSOMES EXTRACTED FROM MAGNETOTACTIC BACTERIA AND SUBMITTED TO AN ALTERNATING MAGNETIC FIELD | ALPHAONCO (FR) | 2017-06-08 | — | — | US | disclosed |
| US-9403731-B2 | Modified aminocarboxylates with improved storage stability and processability | BASF SE (DE) | 2016-08-02 | — | — | US | disclosed |
| EP-2370085-A1 | TREATMENT OF CANCER OR TUMOR INDUCED BY THE RELEASE OF HEAT GENERATED BY VARIOUS CHAINS OF MAGNETOSOMES EXTRACTED FROM MAGNETOTACTIC BACTERIA AND SUBMITTED TO AN ALTERNATIVE MAGNETIC FIELD | Nanobacterie (FR) | 2011-10-05 | — | — | EP | disclosed |
| WO-2011061259-A1 | TREATMENT OF CANCER OR TUMOR INDUCED BY THE RELEASE OF HEAT GENERATED BY VARIOUS CHAINS OF MAGNETOSOMES EXTRACTED FROM MAGNETOTACTIC BACTERIA AND SUBMITTED TO AN ALTERNATIVE MAGNETIC FIELD | NANOBACTERIE (FR) | 2011-05-26 | — | — | WO | disclosed |
| US-20100313620-A1 | CALCIUM FORMIATE FERTILISER | LANXESS DEUTSCHLAND GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| US-20100183741-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-22 | — | — | US | disclosed |
| US-20100160439-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-06-24 | — | — | US | disclosed |
| EP-2167063-A1 | COMPOSITION AND USES OF A RETINOID, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE, IN ACNE | Galderma Research & Development (FR) | 2010-03-31 | — | — | EP | disclosed |
| EP-2167062-A1 | COMPOSITIONS AND USES COMPRISING A RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE IN ACNE | Galderma Research & Development (FR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008152064-A1 | COMPOSITIONS AND USES COMPRISING A RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE IN ACNE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152065-A1 | COMPOSITION AND USES OF A RETINOID, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE, IN ACNE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100183741-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | RARB, RARA, RARG | TRPA1 567/4885CHRM1 1881/4885LMNA 4303/4885 |
| US-20100160439-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | RARB, RARA, RARG | TRPA1 1674/4885CHRM1 2348/4885LMNA 4219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.