Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316879 | 0.91 | METAP2 (0.57) | METAP2SMN1; SMN2ACLYSLC16A3LMNA | |
| SCHEMBL7317403 | 0.88 | METAP2 (0.48) | METAP2SMN1; SMN2PLA2G2ALMNAFFAR4 | |
| SCHEMBL7322650 | 0.81 | METAP2 (0.58) | METAP2SMN1; SMN2FFAR4ALDH1A1MEN1 | |
| SCHEMBL7316525 | 0.80 | ALDH1A1 (0.42) | SMN1; SMN2PLA2G2ALMNAALDH1A1MEN1 | |
| SCHEMBL7318301 | 0.79 | MTNR1A (0.43) | SMN1; SMN2PLA2G2ALMNAFFAR4HTT | |
| SCHEMBL7315387 | 0.78 | FFAR4 (0.44) | METAP2FFAR4ALDH1A1MEN1KMT2A | |
| SCHEMBL7313794 | 0.78 | MTNR1A (0.42) | PLA2G2ALMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7311131 | 0.78 | FFAR4 (0.44) | METAP2SMN1; SMN2LMNAFFAR4HTT | |
| SCHEMBL7321197 | 0.78 | MTNR1A (0.41) | CYP3A4CYP2C19PLA2G2ALMNAFFAR4 | |
| SCHEMBL7322578 | 0.78 | MMP13 (0.45) | METAP2CYP3A4LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |