Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323234 | 0.92 | MMP1 (0.44) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7316400 | 0.90 | MMP9 (0.54) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7316366 | 0.78 | MMP13 (0.42) | MMP1MMP9MMP13ADAM17KEAP1 | |
| SCHEMBL7313728 | 0.75 | MMP1 (0.39) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7315181 | 0.73 | LMNA (0.42) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL7351590 | 0.70 | MMP9 (0.41) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7318168 | 0.70 | MMP1 (0.42) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7316642 | 0.69 | MMP9 (0.48) | MMP1MMP9MMP13ADAM17HTR6 | |
| SCHEMBL7311423 | 0.69 | KDM4E (0.43) | MMP1MMP9MMP13ADAM17LMNA | |
| SCHEMBL7317768 | 0.69 | MMP9 (0.45) | MMP1MMP9MMP13ADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |