Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73189 | 0.78 | CES2 (0.42) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL73188 | 0.78 | CES2 (0.42) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL20204809 | 0.77 | ALDH1A1 (0.46) | CES2CES1ATMCA2LMNA | |
| SCHEMBL1689645 | 0.76 | CES2 (0.41) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL1689646 | 0.76 | CES2 (0.41) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL28072476 | 0.75 | CES2 (0.44) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL1689750 | 0.75 | GSK3B (0.43) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL1689753 | 0.75 | GSK3B (0.43) | CES2CES1TSHRMAPK1ALOX15 | |
| SCHEMBL16933937 | 0.74 | CES1 (0.39) | CES2CES1TSHRMAPK1CYP3A4 | |
| SCHEMBL1283153 | 0.74 | BCL2L1 (0.50) | CES2CES1TSHRMAPK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045422-B2 | Piperidine derivatives with pesticidal properties | SYNGENTA PARTICIPATIONS AG (CH) | 2015-06-02 | — | — | US | disclosed |
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-20140179921-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2014-06-26 | — | — | US | disclosed |
| EP-1755396-B1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | SYNGENTA CROP PROTECTION LLC | 2014-01-30 | — | — | US | disclosed |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-21 | — | — | US | disclosed |
| US-8546569-B2 | Chemical compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130197029-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-01 | — | — | US | disclosed |
| EP-1763302-B1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| EP-1979354-B1 | DIAZA-SPIRO-[4, 5]-DECANES USEFUL AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| EP-1694676-B1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-20090118295-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090042921-A1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| US-20090042938-A1 | Chemical Compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1697376-B1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| US-20070225269-A1 | Use of (3-(1-(3-Phenyl-Propenyl)-Piperidin-4-Yl)-2,3-Dihydro-Indol-1-Yl)-(Pyridin-4-Yl)-Methanonone Derivatives and Related Compounds as Insecticides | SYNGENTA CROP PROTECTION, INC. | 2007-09-27 | — | — | US | disclosed |
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | SYNGENTA CROP PROTECTION, INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042938-A1 | Chemical Compounds | CHRM1, MRM1, H1-0 | CES2 3108/4885CES1 2117/4885TSHR 2317/4885 |
| US-20130197029-A1 | CHEMICAL COMPOUNDS | MRM1, H1-0, RO60 | CES2 3110/4885CES1 2628/4885TSHR 2935/4885 |
| US-20090042921-A1 | SPIROINDOLINE DERIVATIVES HAVING INSECTICIDAL PROPERTIES | CHRM1, CHRM2, ACHE | CES2 2875/4885CES1 2118/4885TSHR 2326/4885 |
| US-20140179921-A1 | CHEMICAL COMPOUNDS | H1-0, REL, ZYX | CES2 2982/4885CES1 3478/4885TSHR 1701/4885 |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, RO60 | CES2 3656/4885CES1 3001/4885TSHR 805/4885 |
| US-20080306101-A1 | Insecticidal Spironindane Derivatives | NR1D1, NR1D2, NR1I3 | CES2 2761/4885CES1 555/4885TSHR 967/4885 |
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | CHRM1, CHRM2, RER1 | CES2 3975/4885CES1 2651/4885TSHR 556/4885 |
| US-20140031378-A1 | INSECTICIDAL SPIRONINDANE DERIVATIVES | NR1D1, NR1D2, NR1I3 | CES2 2761/4885CES1 555/4885TSHR 967/4885 |
| US-20070225269-A1 | Use of (3-(1-(3-Phenyl-Propenyl)-Piperidin-4-Yl)-2,3-Dihydro-Indol-1-Yl)-(Pyridin-4-Yl)-Methanonone Derivatives and Related Compounds as Insecticides | CHRM1, NPY1R, MRM1 | CES2 4607/4885CES1 2314/4885TSHR 1481/4885 |
| US-20130310399-A1 | CHEMICAL COMPOUNDS | ACHE, CHRM1, CHRM2 | CES2 2397/4885CES1 789/4885TSHR 2605/4885 |
| US-20090118295-A1 | CHEMICAL COMPOUNDS | MRM1, MNS1, CHRM1 | CES2 2538/4885CES1 1928/4885TSHR 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.