Sugi Predict

Sugi Predict / Compounds / SCHEMBL731990

SCHEMBL731990

SCHEMBL731990

COc1ccc(CO)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 1/20 0.45
▸ CBFB Q13951 1/20 0.41
▸ PDE10A Q9Y233 2/20 0.40
▸ CA12 O43570 1/20 0.40
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40
▸ CA7 P43166 1/20 0.40
▸ CA9 Q16790 1/20 0.40
▸ CA14 Q9ULX7 1/20 0.40
▸ SLC6A3 Q01959 1/20 0.40
▸ MBOAT4 Q96T53 1/20 0.40
▸ CYP2C9 P11712 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ CYP11B1 P15538 2/20 0.38
▸ CYP11B2 P19099 2/20 0.38
▸ DYRK1A Q13627 1/20 0.38
▸ ADORA2A P29274 1/20 0.38
▸ BACE1 P56817 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29723727 1.00 P2RX7 (0.45) P2RX7CBFBPDE10ACA12CA1
SCHEMBL29723725 1.00 P2RX7 (0.45) P2RX7CBFBPDE10ACA12CA1
SCHEMBL25253178 0.84 PTGS2 (0.40) P2RX7CBFBCA12CA1CA2
SCHEMBL12036832 0.82 FYN (0.40) P2RX7CBFBSLC6A3
SCHEMBL4292198 0.82 LTA4H (0.50) P2RX7CYP11B1CYP11B2ALDH1A1HPGD
SCHEMBL29550500 0.82 NQO1 (0.50) TSHR
SCHEMBL23554538 0.82 NQO1 (0.50) TSHR
SCHEMBL17544106 0.81 CBFB (0.46) CBFB
SCHEMBL1581469 0.81 PDE10A (0.43) PDE10ACA12CA1CA2CA7
SCHEMBL23530082 0.80 HRH3 (0.40) CBFB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US claimed
EP-3197277-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-12-22 — — EP claimed
US-20210380608-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-12-09 — — US claimed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP claimed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US claimed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US claimed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US claimed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US claimed
EP-3340796-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2018-07-04 — — EP claimed
US-20170283439-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CCHDI Foundation Inc. (US) 2017-10-05 — — US claimed
EP-3197277-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-08-02 — — EP claimed
WO-2017040336-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2017-03-09 — — WO claimed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US claimed
WO-2016033440-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
WO-2013062966-A2 NOVEL TRPV3 MODULATORS ABBVIE INC. (US) 2013-05-02 — — WO claimed
US-12606570-B2 Deuterated compounds and imaging agents for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2026-04-21 — — US disclosed
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2026-03-19 — — US disclosed
EP-0920424-A1 NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-06-09 — — EP disclosed
WO-1998007718-A1 NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-02-26 — — WO disclosed
US-4230714-A Imidazole therapeutic agents PFIZER INC. (US) 1980-10-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12606570-B2 Deuterated compounds and imaging agents for imaging huntingtin protein HTT, HYPK, ATXN2 P2RX7 4043/4885CBFB 977/4885PDE10A 3288/4885
US-11344637-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF NAMPT, NNMT, SARM1 P2RX7 1057/4885CBFB 3339/4885PDE10A 1264/4885
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-20210380608-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-20170283439-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-10765764-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 P2RX7 4721/4885CBFB 968/4885PDE10A 3407/4885
US-10137211-B2 Probes for imaging Huntingtin protein HTT, HYPK, FABP7 P2RX7 4663/4885CBFB 633/4885PDE10A 3552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.